Recombinant Human Fragile X mental retardation syndrome-related protein 1 (FXR1), partial

• Product Name Alternative:

  (FMR1 autosomal homolog 1) (hFXR1p)

• Abbreviation:

  Recombinant Human FXR1 protein, partial

• Gene Name:

  FXR1

• UniProt:

  P51114

• Expression Region:

  354-621aa

• Organism:

  Homo sapiens (Human)

• Target Sequence:

  HIAYLKEVEQLRMERLQIDEQLRQIGSRSYSGRGRGRRGPNYTSGYGTNSELSNPSETESERKDELSDWSLAGEDDRDSRHQRDSRRRPGGRGRSVSGGRGRGGPRGGKSSISSVLKDPDSNPYSLLDNTESDQTADTDASESHHSTNRRRRSRRRRTDEDAVLMDGMTESDTASVNENGLVTVADYISRAESQSRQRNLPRETLAKNKKEMAKDVIEEHGPSEKAINGPTSASGDDISKLQRTPGEEKINTLKEENTQEAAVLNGVS

• Tag:

  C-terminal 6xHis-tagged

• Type:

  In Stock Protein

• Source:

  E.coli

• Field of Research:

  Epigenetics and Nuclear Signaling

• Relevance:

  RNA-binding protein required for embryonic and postnatal development of muscle tissue . May regulate intracellular transport and local translation of certain mRNAs .

• Endotoxin:

  Not test

• Purity:

  Greater than 85% as determined by SDS-PAGE.

• Activity:

  Not Test

• Form:

  Liquid or Lyophilized powder

• Buffer:

  If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.

• Reconstitution:

  We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%. Customers could use it as reference.

• Molecular Weight:

  30.7 kDa

• References & Citations:

  "Recessive mutations in muscle-specific isoforms of FXR1 cause congenital multi-minicore myopathy." Estan M.C., Fernandez-Nunez E., Zaki M.S., Esteban M.I., Donkervoort S., Hawkins C., Caparros-Martin J.A., Saade D., Hu Y., Bolduc V., Chao K.R., Nevado J., Lamuedra A., Largo R., Herrero-Beaumont G., Regadera J., Hernandez-Chico C., Tizzano E.F. Ruiz-Perez V.L. Nat. Commun. 10:797-797 (2019)

• Storage Conditions:

  The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

• Protein Length:

  Partial