Recombinant Human Solute carrier family 2, facilitated glucose transporter member 9 (SLC2A9)

• Product Name Alternative:

  (Glucose transporter type 9) (GLUT-9) (Urate transporter)

• Abbreviation:

  Recombinant Human SLC2A9 protein

• Gene Name:

  SLC2A9

• UniProt:

  Q9NRM0

• Expression Region:

  1-540aa

• Organism:

  Homo sapiens (Human)

• Target Sequence:

  MARKQNRNSKELGLVPLTDDTSHAGPPGPGRALLECDHLRSGVPGGRRRKDWSCSLLVASLAGAFGSSFLYGYNLSVVNAPTPYIKAFYNESWERRHGRPIDPDTLTLLWSVTVSIFAIGGLVGTLIVKMIGKVLGRKHTLLANNGFAISAALLMACSLQAGAFEMLIVGRFIMGIDGGVALSVLPMYLSEISPKEIRGSLGQVTAIFICIGVFTGQLLGLPELLGKESTWPYLFGVIVVPAVVQLLSLPFLPDSPRYLLLEKHNEARAVKAFQTFLGKADVSQEVEEVLAESRVQRSIRLVSVLELLRAPYVRWQVVTVIVTMACYQLCGLNAIWFYTNSIFGKAGIPPAKIPYVTLSTGGIETLAAVFSGLVIEHLGRRPLLIGGFGLMGLFFGTLTITLTLQDHAPWVPYLSIVGILAIIASFCSGPGGIPFILTGEFFQQSQRPAAFIIAGTVNWLSNFAVGLLFPFIQKSLDTYCFLVFATICITGAIYLYFVLPETKNRTYAEISQAFSKRNKAYPPEEKIDSAVTDGKINGRP

• Tag:

  N-terminal 10xHis-tagged

• Type:

  CF Transmembrane Protein & In Stock Protein

• Source:

  In vitro E.coli expression system

• Field of Research:

  Metabolism

• Relevance:

  High-capacity urate transporter, which may play a role in the urate reabsorption by proximal tubules . May have a residual high-affinity, low-capacity glucose and fructose transporter activity . Transports urate at rates 45- to 60-fold faster than glucose . Does not transport galactose . May mediate small uptake of adenine but not of other nucleobases .

• Endotoxin:

  Not test

• Purity:

  Greater than 85% as determined by SDS-PAGE.

• Activity:

  Not Test

• Form:

  Liquid or Lyophilized powder

• Buffer:

  If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.

• Reconstitution:

  We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%. Customers could use it as reference.

• Molecular Weight:

  60.2 kDa

• References & Citations:

  "SLC2A9 is a high-capacity urate transporter in humans." Caulfield M.J., Munroe P.B., O'Neill D., Witkowska K., Charchar F.J., Doblado M., Evans S., Eyheramendy S., Onipinla A., Howard P., Shaw-Hawkins S., Dobson R.J., Wallace C., Newhouse S.J., Brown M., Connell J.M., Dominiczak A., Farrall M. Cheeseman C. PLoS Med. 5:e197-e197 (2008)

• Storage Conditions:

  The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

• Protein Length:

  Full Length