Recombinant Human Claudin-18.2 (CLDN18.2) -Detergent (Active)

• CAS Number:

  9000-83-3

• Gene Name:

  CLDN18.2

• UniProt:

  P56856-2

• Expression Region:

  1-261aa

• Organism:

  Homo sapiens

• Target Sequence:

  MAVTACQGLGFVVSLIGIAGIIAATCMDQWSTQDLYNNPVTAVFNYQGLWRSCVRESSGFTECRGYFTLLGLPAMLQAVRALMIVGIVLGAIGLLVSIFALKCIRIGSMEDSAKANMTLTSGIMFIVSGLCAIAGVSVFANMLVTNFWMSTANMYTGMGGMVQTVQTRYTFGAALFVGWVAGGLTLIGGVMMCIACRGLAPEETNYKAVSYHASGHSVAYKPGGFKASTGFGSNTKNKKIYDGGARTEDEVQSYPSKHDYV

• Tag:

  C-terminal 10xHis-tagged

• Source:

  Mammalian cell

• Field of Research:

  Signal Transduction

• Assay Type:

  MP-Detergent Transmembrane Protein & Active Protein & In Stock Protein

• Relevance:

  Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.

• Purity:

  Greater than 80% as determined by SDS-PAGE.

• Activity:

  Yes

• Bioactivity:

  Measured by its binding ability in a functional ELISA. Immobilized Human CLDN18.2 at 5 μg/mL on an Nickel Coated plate can bind Anti-CLDN18.2 recombinant antibody (CSB-RA005505MA1HU), the EC50 is 0.4640-0.6372 ng/mL.

• Length:

  Full Length of Isoform A2

• Form:

  Liquid

• Buffer:

  50 mM HEPES，0.15 M NaCl， 0.05% DDM，0.01% CHS，pH7.5

• Molecular Weight:

  29.1 kDa

• References & Citations:

  "Claudin-18 splice variant 2 is a pan-cancer target suitable for therapeutic antibody development." Sahin U., Koslowski M., Dhaene K., Usener D., Brandenburg G., Seitz G., Huber C., Tuereci O. Clin. Cancer Res. 14:7624-7634 (2008)

• Storage Conditions:

  The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20℃/-80℃. The shelf life of lyophilized form is 12 months at -20℃/-80℃.